Tomyris was a queen of the Massagetae (c. 530 BC). After she found out about the death of her son, Spargapises, at the hands of Cyrus the Great she led the Massagetean army into war, and, during the battle defeated the Persians and destroyed most of their army.
Queen Adad-Guppi was the daughter of King Ashurbanipal and Ashursharrat l… and mother to King Nabonidus. It’s been suggested that she acted as a regent for Nabonidus when he abandoned Babylon in 552 BC for Tema. The Tema Stele (c. 6 century BC), represent an important part of the history of Tema and of the history of the Arabian Peninsula.
Queen Jezebel married King Ahab (r. 874-853 BC), of Samaria, the northern kingdom of Israel. Her daughter, Athaliah, was queen of Judah (r. 841–835 BC) and the only female monarch to sit on David’s throne in biblical history.
Queen Artemisia I was of Carian-Greek ethnicity by her father Lygdamis I (r. 520-484 BC), and half-Cretan by her mother. She took the throne after the death of her husband.
Some sources state that Sagburu of Ereš became embroiled in a plot to overthrow Esarhaddon c. 671 BC. Others that she aided King Enmerkar of Uruk (c. 3100 BC), to defeat his arch-nemesis, the king of Aratta, in Enmerkar and Enšukešdana.