Sources state that Sagburu, Oracle of Nuska, aided King Enmerkar of Uruk (c. 3100 BC), to defeat his arch-nemesis, the king of Aratta, in Enmerkar and Ensukesdana.
Šērūʾa-ēṭirat was the eldest daughter of Assyrian King Esarhaddon (r. 681-669 BC) and the older sister of twins, Ashurbanipal and Šamaš-šuma-ukin, crown princes of Assyria and of Babylonia. She was likely involved in politics.
Queen Naqiya-Zakutu was the wife of King Sennacherib, mother of King Esarhaddon, and grandmother of Ashurbanipal of Assyria's final ruling dynasty, the Sargonid Dynasty.
Queen Sammu-Ramat was the wife and queen of King Shamshi-Adad V (r. 824-811 BC), a son and successor of King Shalmaneser III. Around 806 BC, her son, King Adad-Nirari III was at an age where he could take on the full responsibility of the Assyrian throne.
Enheduanna was the daughter of Sargon of Akkad, and composed 42 temple hymns and three stand-alone poems that are considered an important part of Mesopotamia's literary legacy.